Microbiota-gut-brain axis and the central nervous system
نویسندگان
چکیده
The gut and brain form the gut-brain axis through bidirectional nervous, endocrine, and immune communications. Changes in one of the organs will affect the other organs. Disorders in the composition and quantity of gut microorganisms can affect both the enteric nervous system and the central nervous system (CNS), thereby indicating the existence of a microbiota-gut-brain axis. Due to the intricate interactions between the gut and the brain, gut symbiotic microorganisms are closely associated with various CNS diseases, such as Parkinson's disease, Alzheimer's disease, schizophrenia, and multiple sclerosis. In this paper, we will review the latest advances of studies on the correlation between gut microorganisms and CNS functions & diseases.
منابع مشابه
Interaction between Intestinal Microbiota and Serotonin Metabolism
Gut microbiota regulates the production of signaling molecules, such as serotonin or 5-Hydroxytryptamine: 5-HT in the host. Serotonin is a biogenic amine that acts as a neurotransmitter in the gut and brain. There is a perfect interaction between human gastrointestinal microbiota and the serotonin system. The gut microbiota plays an important role in the serotonin signaling pathways through the...
متن کاملP 119: Role of Gut Bacteria on Alzheimer’s Disease
Alzheimer’s disease (AD) is a neurodegenerative disease that is the most common type of dementia.AD includes 60_80% of dementia and most people with AD have more than 65 years old.AD causes losing neuronal activity by abnormal proteins. Plaques of beta-amyloid and tangles of “tau” protein can lead to AD. Recently evidence has found that AD may come from outside of central nerv...
متن کاملA review on pathophysiology of irritable bowel syndrome with emphasis on the role of brain factors
Irritable bowel syndrome (IBS) is a common and chronic functional gastrointestinal disorder that causes a great burden on the individual and society. Despite many studies, there is no consent about the etiology, diagnostic and treatment method of IBS. In recent years, neurologic factors have been given attention for better understanding and management of this disorder. The aim of the present st...
متن کاملPsychobiotics and Brain-Gut Microbiota Axis
Fermented foods containing probiotic bacteria have been used for many years to improve the health or treatment of some diseases. Nowadays, the Therapeutic properties of probiotics are becoming more and more obvious to everyone, insofar as in recent years, more attention has been paid to the potential relation between gut microbiota and mental health. Several studies have shown that intestinal m...
متن کاملThe gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems
The gut-brain axis (GBA) consists of bidirectional communication between the central and the enteric nervous system, linking emotional and cognitive centers of the brain with peripheral intestinal functions. Recent advances in research have described the importance of gut microbiota in influencing these interactions. This interaction between microbiota and GBA appears to be bidirectional, namel...
متن کاملGut-Microbiota and Mental Health: Current and Future Perspectives
Recently, there is a growing interest of research on the relationship of gut-microbiota and neurological disorders. Increasing number of findings suggests the broader role of gut-microbiota in the modulation of various physiological and pathological conditions and it is now well recognized that a bidirectional communication between brain and gut-microbiota is essential to maintain homeostasis. ...
متن کامل